Siamak Rimaz; Vahideh Abdi; Cyrus Emir Alavi; Sanaz Masoumi; Mahsa Sadeghi; Mohammadreza Mobayen; Parissa Bagheri
Volume 13, Issue 2 , April 2025, , Pages 83-89
Abstract
Objectives: This study aimed to determine the survival rate and identify associated risk factors in mechanically ventilated (MV) burn patients.
Methods: This cross-sectional analytical study was conducted at Velayat Hospital, a burn and plastic surgery referral center affiliated with Guilan University ...
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Objectives: This study aimed to determine the survival rate and identify associated risk factors in mechanically ventilated (MV) burn patients.
Methods: This cross-sectional analytical study was conducted at Velayat Hospital, a burn and plastic surgery referral center affiliated with Guilan University of Medical Sciences, between March 2011, and September 2020. Data were retrieved from electronic medical records and analyzed using SPSS software (version 24.0). Patients discharged alive or lost to follow-up were treated as censored observations in a time-to-event analysis.
Results: The mean age of survivors was 19.03±30.21 years, compared to 42.54±19.30 years in the non-survivors. Men comprised 78.9% (n=30) of survivors and 64.9% (n=155) of non-survivors. The mean intensive care unit (ICU) survival time was 18.33±1.36 days (median=12±1.24 days). There were significant differences between survivor and non-survivor groups in terms of age, length of stay, presence of comorbidities, inhalation injury, sepsis, acute respiratory distress syndrome (ARDS), and acute kidney injury (AKI) (p<0.05). The Kaplan-Meier analysis demonstrated a significant difference in survival probability between MV and non-MV groups (p=0.028), with a higher survival probability observed in non-MV patients.
Conclusion: Age, length of stay, renal failure, ARDS, and sepsis were associated with increased mortality risk in MV burn patients. While these findings highlighted critical prognostic factors, causal inferences require further investigation through longitudinal or interventional studies to guide targeted therapeutic strategies.
Maryam Ramezanian; Parissa Bagheri; Cyrus Emir Alavi; Mohaya Farzin; MohammadReza Mobayen; Moein Moghaddam Ahmadi; Mohammad Tolouei; Siamak Rimaz; Mehdi Karimian; Hojat Eftekhari; Kiana Baghi; Ali Shabbak
Volume 13, Issue 1 , January 2025, , Pages 47-52
Abstract
Objectives: Severe burns often result in significant intravascular albumin loss, leading to hypoalbuminemia. This study aimed to evaluate the association between serum albumin levels and clinical outcomes in burn patients.Methods: A retrospective, single-center study was conducted at Velayat Hospital ...
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Objectives: Severe burns often result in significant intravascular albumin loss, leading to hypoalbuminemia. This study aimed to evaluate the association between serum albumin levels and clinical outcomes in burn patients.Methods: A retrospective, single-center study was conducted at Velayat Hospital (Rasht, Iran), including burn patients aged ≥16 years, who were admitted between April 2019 and March 2020. Serum albumin levels were recorded on day 1, day 7, and at discharge. The main variables analyzed included albumin levels, length of hospital stay, skin graft rate, need for mechanical ventilation, and mortality.Results: Among the 74 patients included in the study, 14 (18.9%) died, while 60 (81.1%) survived. The mean serum albumin levels on days 1, 7, and at discharge were significantly higher in survivors (3.09±0.22, 3.12±0.23, and 3.18±0.28 g/dL, respectively) than non-survivors (2.22±0.29, 2.74±0.29, and 2.07±0.69 g/dL, respectively) at all time points (p<0.001). The serum albumin level measured on day 1 was significantly lower in patients who required mechanical ventilation than in those who did not (2.86±0.47 vs.3.09±0.13, p=0.03). Additionally, a significant inverse relationship was observed between serum albumin levels and both total body surface area burned (TBSA) and graft extent (day 1: rs=-0.76, day 7: rs=-0.74, discharge: rs=−0.62; p<0.001 for TBSA; and day 1: rs=-0.59, day 7: rs=-0.58, discharge: rs=−0.50; p<0.001 for graft extent). Conclusion: Hypoalbuminemia was associated with poor clinical outcomes in patients with severe burns. Serum albumin levels might serve as a specific marker of burn severity and a predictor of mortality.
