Siamak Rimaz; Vahideh Abdi; Cyrus Emir Alavi; Sanaz Masoumi; Mahsa Sadeghi; Mohammadreza Mobayen; Parissa Bagheri
Articles in Press, Accepted Manuscript, Available Online from 14 May 2025
Abstract
Objective: Burn injuries are a significant public health concern, contributing substantially to morbidity and mortality rates. Mechanical ventilation (MV) is crucial in managing critically ill patients with extensive burns. This study aimed to determine the survival rate of burn patients under mechanical ...
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Objective: Burn injuries are a significant public health concern, contributing substantially to morbidity and mortality rates. Mechanical ventilation (MV) is crucial in managing critically ill patients with extensive burns. This study aimed to determine the survival rate of burn patients under mechanical ventilation and identify the risk factors related to it. Methods: A cross-sectional analytical study was conducted at Velayat Hospital, affiliated with Guilan University of Medical Sciences, between March 21, 2011, and September 21, 2020. Data were retrieved from electronic hospital records and analyzed using SPSS version 28. Results: The mean age of survivors was 19.03±30.21 years, contrasting with 42.54±19.30 years in the deceased group. Among survivors, 30 were male (78.9%), while in the deceased group, 155 were male (64.9%). The average survival time in the intensive care unit was 18.33±1.36 days, with a median survival of 12±1.24 days. Significant differences were observed in age, length of stay, comorbidity, inhalation injury, sepsis, acute respiratory distress syndrome (ARDS), and acute kidney injury (AKI) between survivor and non-survivor groups (P<0.05). The Kaplan-Meier curve demonstrated a significant difference in survival probability between MV and non-MV groups (P=0.028), with higher survival probability observed in non-MV patients.Conclusion: Our findings indicate that factors such as age, length of stay, renal failure, ARDS, and sepsis are associated with increased mortality risk in mechanically ventilated burn patients. While these associations provide critical insights into potential risk factors, they should not be interpreted as causal relationships. Future research should explore these associations through interventional or longitudinal studies to establish causality and refine treatment strategies.
Maryam Ramezanian; Parissa Bagheri; Cyrus Emir Alavi; Mohaya Farzin; MohammadReza Mobayen; Moein Moghaddam Ahmadi; Mohammad Tolouei; Siamak Rimaz; Mehdi Karimian; Hojat Eftekhari; Kiana Baghi; Ali Shabbak
Volume 13, Issue 1 , January 2025, , Pages 47-52
Abstract
Objectives: Severe burns often result in significant intravascular albumin loss, leading to hypoalbuminemia. This study aimed to evaluate the association between serum albumin levels and clinical outcomes in burn patients.Methods: A retrospective, single-center study was conducted at Velayat Hospital ...
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Objectives: Severe burns often result in significant intravascular albumin loss, leading to hypoalbuminemia. This study aimed to evaluate the association between serum albumin levels and clinical outcomes in burn patients.Methods: A retrospective, single-center study was conducted at Velayat Hospital (Rasht, Iran), including burn patients aged ≥16 years, who were admitted between April 2019 and March 2020. Serum albumin levels were recorded on day 1, day 7, and at discharge. The main variables analyzed included albumin levels, length of hospital stay, skin graft rate, need for mechanical ventilation, and mortality.Results: Among the 74 patients included in the study, 14 (18.9%) died, while 60 (81.1%) survived. The mean serum albumin levels on days 1, 7, and at discharge were significantly higher in survivors (3.09±0.22, 3.12±0.23, and 3.18±0.28 g/dL, respectively) than non-survivors (2.22±0.29, 2.74±0.29, and 2.07±0.69 g/dL, respectively) at all time points (p<0.001). The serum albumin level measured on day 1 was significantly lower in patients who required mechanical ventilation than in those who did not (2.86±0.47 vs.3.09±0.13, p=0.03). Additionally, a significant inverse relationship was observed between serum albumin levels and both total body surface area burned (TBSA) and graft extent (day 1: rs=-0.76, day 7: rs=-0.74, discharge: rs=−0.62; p<0.001 for TBSA; and day 1: rs=-0.59, day 7: rs=-0.58, discharge: rs=−0.50; p<0.001 for graft extent). Conclusion: Hypoalbuminemia was associated with poor clinical outcomes in patients with severe burns. Serum albumin levels might serve as a specific marker of burn severity and a predictor of mortality.
