Document Type : Original Article
Authors
- Maryam Ramezanian 1
- Parissa Bagheri 2
- Cyrus Emir Alavi 3
- Mohaya Farzin 4
- MohammadReza Mobayen 5
- Moein Moghaddam Ahmadi 6
- Mohammad Tolouei 7
- Siamak Rimaz 8
- Mehdi Karimian 9
- Hojat Eftekhari 10
- Kiana Baghi 11
- Ali Shabbak 7
1 Burn and Regenerative Medicine Research Center, Guilan University of Medical Sciences, Rasht, Iran.
2 1) Burn and Regenerative Medicine Research Center, Guilan University of Medical Sciences, Rasht, Iran. 2. Medical Education Research Center, Education Development Center, Guilan University of Medical Sciences, Rasht, Iran
3 Razi Clinical Research Development Unit, Guilan University of Medical Sciences, Rasht. Iran
4 Department of Physiology, Razi Clinical Research Development Center, Guilan University of Medical Sciences, Rasht, Iran
5 Burn and Regenerative Medicine Research center, Guilan University of Medical Sciences,Rasht, Iran.
6 Poursina Clinical Research Development Unit, Guilan University of Medical Sciences, Rasht. Iran
7 Burn and Regenerative Medicine Research Center, Guilan University of Medical Sciences, Rasht, Iran
8 1. Burn and Regenerative Medicine Research Center, Guilan University of Medical Sciences, Rasht, Iran
9 Surgery Department of Manzarieh Hospital, Khomeini Shahr, Isfahan, Iran
10 Skin Research Center, Department of Dermatology, Razi Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran
11 4. Poursina Clinical Research Development Unit, Guilan University of Medical Sciences, Rasht. Iran
Abstract
Background: Severe burns cause significant intravascular albumin loss, leading to hypoalbuminemia. This study evaluated the association between serum albumin levels and clinical outcomes in burn patients.
Methods: A retrospective, single-center study was conducted at Velayat Hospital, including burn patients aged ≥16 admitted between April 2019 and March 2020. Serum albumin levels were recorded on day 1, day 7, and at discharge. The main variables included albumin levels, length of stay, skin graft rate, mechanical ventilation, and mortality.
Results: Among the 74 patients in the study, 14 (18.9%) died, while 60 (81.1%) survived. The mean serum albumin levels at days 1, 7, and discharge were significantly higher in survivors (3.09 ± 0.22, 3.12 ± 0.23, and 3.18 ± 0.28 g/dL, respectively) compared to nonsurvivors (2.22 ± 0.29, 2.74 ± 0.29, and 2.07 ± 0.69 g/dL, respectively) at all time points (P < 0.001). The serum albumin level measured on day 1 was significantly lower in patients who required mechanical ventilation than those without mechanical ventilation (2.86±0.47 vs.3.09±0.13, P=0.03). Additionally, an inverse and significant relationship was found between serum albumin levels and both total body surface area burned (TBSA) and graft extent (day 1: rs =-0.76, day 7: rs =-0.74, discharge: rs =−0.62; P<0.001 for TBSA; and day 1: rs =-0.59, day 7: rs =-0.58, discharge: rs =−0.50; P<0.001 for graft extent)
Conclusion: Hypoalbuminemia is associated with poor outcomes in patients with severe burns. Serum albumin levels may serve as a specific marker of burn severity and a predictor of mortality.
Keywords
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