sayyed majid sadrzadeh; Vahid Talebzadeh; Seyed Mohamad Mousavi; Behrang Rezvani Kakhki; elnaz vafadar moradi; Hamideh Feiz Disfani
Volume 13, Issue 1 , January 2025, , Pages 32-36
Abstract
Objectives: This study aimed to investigate the prognostic role of lactate clearance in predicting outcomes among trauma patients admitted to the emergency department.Methods: This retrospective cohort study was conducted on patients referred to the Emergency Department. Serum lactate levels were measured ...
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Objectives: This study aimed to investigate the prognostic role of lactate clearance in predicting outcomes among trauma patients admitted to the emergency department.Methods: This retrospective cohort study was conducted on patients referred to the Emergency Department. Serum lactate levels were measured at admission and 2 hours later. The patients were followed up for 72 hours to assess outcomes, including discharge, hospitalization in other wards, and mortality.Results: The results showed a significant difference between the mean age, Glasgow Coma Scale (GCS), systolic blood pressure (SBP), pulse rate (PR), and oxygen saturation (O2 Sat) of the trauma patients in relation to mortality prognosis (p<0.05). Additionally, significant differences were found in primary lactate, lactate levels two hours post-admission, and lactate clearance levels based on the patient’s prognosis (p<0.01). Multivariate logistic regression analysis revealed that lactate clearance was associated with a reduced mortality rate among trauma patients (OR=0.907, p<0.05).Conclusion: The findings of this study showed that lactate clearance, as an independent predictive factor, was associated with poorer prognosis and increased mortality rates in trauma patients.
Elham Safari; Mehdi Torabi
Volume 8, Issue 2 , April 2020, , Pages 83-88
Abstract
Objective: To investigate the relationship between end-tidal CO2 (ETCO2) and serum lactate and their predictive role in hospital mortality of intubated multiple trauma patients. Methods: In a cohort study, intubated multiple trauma patients who referred to the emergency department for two years were ...
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Objective: To investigate the relationship between end-tidal CO2 (ETCO2) and serum lactate and their predictive role in hospital mortality of intubated multiple trauma patients. Methods: In a cohort study, intubated multiple trauma patients who referred to the emergency department for two years were enrolled. After orotracheal intubation using Rapid Sequence Intubation (RSI) method, ETCO2 was immediately measured by capnography. Blood samples for serum lactate measurements were sent to the laboratory, immediately after intubation. Data collection was done using the questionnaire, and the patients were followed using their medical records. Results: Totally, 250 patients were included with hospital mortality of 14.8% (n=37). Using Pearson correlation, an inverse relationship was noticed between serum lactate and ETCO2, immediately (p<0.0001, r=-0.65). In adjusted multivariate analysis, three variables including heart rate (HR), serum lactate and ETCO2 showed a significant relationship with hospital mortality, respectively (p=0.007, p=0.009, p=0.023, respectively). Receiver operating characteristic curve illustrated an area under the curve (AUC) of 0.93, 0.96, and 0.97 for HR, lactate, and ETCO2, respectively. Conclusion: ETCO2 post-intubation and serum lactate may be considered as prognostic factors for intubated multiple trauma patients referring to the emergency department, which can give the clinician an important clue in early prediction of the hospital mortality.
