Document Type : Original Article
Authors
- sayyed majid sadrzadeh 1
- Vahid Talebzadeh 2
- Seyed Mohamad Mousavi 3
- Behrang Rezvani Kakhki 3
- elnaz vafadar moradi 4
- Hamideh Feiz Disfani 5
1 1. Assistant professor of Emergency Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
2 Department of Emergency Medicine, School of Medicine, Gonabad University of Medical Sciences, Gonabad, Iran
3 Department of Emergency Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
4 Assistant professor of Emergency Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
5 Department of Emergency Medicine, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Abstract
Background: Lactate clearance can be considered as a prognostic biomarker associated with the mortality rate and hospital stay of trauma patients. The present study aimed to investigate the prognostic role of lactate clearance associated with the incidence of trauma patients’ outcomes.
Methods: This retrospective cohort study was conducted on the people who were referred to the emergency department. The serum lactate levels of the subjects were measured at admission and 2 hours later. The patients were followed up within 72 hours in terms of discharge, hospitalization in other wards, and mortality.
Results: The results showed a significant difference between the mean age, GCS (Glasgow Coma Scale), SBP (systolic blood pressure), PR (pulse rate), and O2 Sat of the trauma patients concerning their death prognosis (P value<0.05). There was also a significant difference between primary lactate, two-hour-later lactate, and lactate clearance levels according to the patient's prognosis (P value<0.01). The results of the multivariate logistic regression indicated that lactate clearance was associated with a decrease in the mortality rate of trauma patients (OR=0.907, P value<0.05).
Conclusion: The results of this study showed well that as an independent predictive factor, the lactate clearance level was associated with a worse prognosis and increased mortality rates of the patients.
Keywords
)