Atefeh Ghanbari; Sanaz Masoumi; Ehsan Kazemnejadleili; Marjan Mahdavi-Roshan; MohammadReza Mobayen
Volume 11, Issue 1 , January 2023, , Pages 32-40
Abstract
Objectives: To study the anti-inflammatory and antioxidant effects of flaxseed oil and olive oil on inflammatorymarkers for facilitating wound healing.Methods: One hundred and twelve patients were randomly selected to four groups with a total burn surfacearea (TBSA) of 20-50%. The four groups includes ...
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Objectives: To study the anti-inflammatory and antioxidant effects of flaxseed oil and olive oil on inflammatorymarkers for facilitating wound healing.Methods: One hundred and twelve patients were randomly selected to four groups with a total burn surfacearea (TBSA) of 20-50%. The four groups includes olive oil (OO), flaxseed oil (FO), mixture of olive oil andflaxseed oil (OF), and control group and received 30g of oils for three weeks. Serum high-sensitivity C-reactiveprotein (hs-CRP), ferritin and albumin level as inflammatory markers, as well as cholesterol, triglyceride,high-density lipoprotein (HDL) and low-density lipoprotein (LDL) as the lipid profile were explored. Woundhealing was assessed by photographing on days 2, 8, 15, and 22 (during three weeks of intervention) and wereanalyzed in imageJ software.Results: The greatest reduction in the level of hs-CRP and ferritin was observed in the OF (-21.38±44.41)(-132.79±165.36), while the lowest reduction was reported in the control group (-36.36±79.03) (141.08±262.36).Compared to control group, OO significantly increased albumin (0.88±0.65). Reduction of wound healing at theend of the first week of intervention was not significant in the study groups. However, the stereology examinationshowed significant improvement in wound healing at the end of the second and third weeks in the OF.Conclusion: Based on the findings, combination of herbal oils reduce inflammation and improve wound healingand showed positive effects on the size of wounds in burn patients.
Mehdi Ayaz
Volume 9, Issue 2 , April 2021, , Pages 96-100
Abstract
Introduction: Wound debridement is necessary before skin grafting or wound closure. Inappropriate wound bed preparation will led to graft rejection and sometimes catastrophic results, especially in large wounds,. Usage of popular debridement and excision devices such as dermatomes has some ...
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Introduction: Wound debridement is necessary before skin grafting or wound closure. Inappropriate wound bed preparation will led to graft rejection and sometimes catastrophic results, especially in large wounds,. Usage of popular debridement and excision devices such as dermatomes has some difficulties and disadvantages. In this study we will introduce metallic scrub sponge as a safe and effective debridement device.Methods: The surgeon usually uses a sterile metallic scrub sponge over the wound with transverse or rotational repeated movement. Wound preparing with metallic sponge should be stopped when pinpoint bleeding occurs. We used sterile metallic sponge for more than 2500 burn patients.Results: The results are excellent for deep second degree burn (and deeper burns at least 5-10 days after burn when some eschar loosening occurs). Work with scrub sponge was effective, fast and safe.Discussion: Metallic scrub sponge is a useful device for wound preparation due to its some special characteristics. Debridement of the burn wound with metallic sponge can preserve the spontaneous epithelialization potential of skin in second degree burns and reduce additional injury to the viable tissue that is inevitable by surgical debridement. Cost effectiveness, easy accessibility, safety, softness, inertness and some others are among the other advantages of metallic sponge usage for wound preparation.Conclusion: Due to metallic sponge’s simplicity and capability to remove necrotic loose tissues and easy accessibility everywhere and minimal adverse effects, it is a good first line tool for wound preparation and debridement.
Amin Nikpasand; mohammad reza parvizi
Volume 7, Issue 4 , October 2019, , Pages 366-372
Abstract
Objective: To evaluate effects of titanium dioxide /gelatin nanocomposite on wound healing in mice as a model study. Methods: Fifty male rats were randomized into five groups of ten animals each. In group I, 0.1 mL sterile saline 0.9% solution was added to the wounds with no infection. In group ...
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Objective: To evaluate effects of titanium dioxide /gelatin nanocomposite on wound healing in mice as a model study. Methods: Fifty male rats were randomized into five groups of ten animals each. In group I, 0.1 mL sterile saline 0.9% solution was added to the wounds with no infection. In group II, the wounds were infected with MRSA and only treated with 0.1 mL the sterile saline 0.9% solution. In group III, infected wounds were treated with gelatin. In group IV, animals with infected wounds were treated with 0.1 mL titanium dioxide nanoparticles. In group V, animals with infected wounds were treated with titanium dioxide /gelatin nanocomposite. Wound size was measured on 2, 6, 10, 14, 18 and 20 days after surgery. Results: Reduction in wound area indicated that there was significant difference between group IV and other groups (p <0.05). Quantitative histological and morphometric studies and mean rank of the qualitative studies demonstrated that there was significant difference between group IV and other groups (p <0.05). Conclusion: Titatnium dioxide nanoparticles/gelatin composite offered potential advantages in wound healing acceleration and fibroblast proliferation on early days of healing phases. Acceleration in wound repair could be associated with earlier wound contraction and stability of damaged area by rearrangement of granulation tissue and collagen fibers.
Reza Ranjbar; Alireza Yousefi
Volume 6, Issue 1 , January 2018, , Pages 8-15
Abstract
Objective: To assess effect of Aleo vera with chitosan nanoparticle biofilm on wound healing in full thickness infected wounds with antibiotic resistant gram positive bacteria.Method: Thirty rats were randomized into five groups of six rats each. Group I: Animals with uninfected wounds treated with 0.9% ...
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Objective: To assess effect of Aleo vera with chitosan nanoparticle biofilm on wound healing in full thickness infected wounds with antibiotic resistant gram positive bacteria.Method: Thirty rats were randomized into five groups of six rats each. Group I: Animals with uninfected wounds treated with 0.9% saline solution. Group II: Animals with infected wounds treated with saline. Group III: Animals with infected wounds were dressed with chitosan nanoparticle thin-film membranes. Group IV: Animals with infected wounds were treated topically with Aloe vera and Group V: Animals with infected wounds were treated topically with Aloe vera and dressed with chitosan nanoparticle thin-film membranes. Wound size was measured on 6, 9, 12, 15, 18 and 21days after surgery.Results: Microbiology, reduction in wound area and hydroxyproline contents indicated that there was significant difference (p<0.05) between group V and other groups. Quantitative histological studies and mean rank of the qualitative studies demonstrated that there was significant difference (p<0.05) between group V and other groups.Conclusion: The Aloe vera with chitosan nanoparticle thin-film membranes had a reproducible wound healing potential and hereby justified its use in practice.
