Document Type : Original Article

Authors

1 Department of Nursing (Medical‑Surgical), Social Determinants of Health Research Center (SDHRC), School of Nursing and Midwifery, Guilan University of Medical Sciences, Rasht, Iran

2 Burn and Regenerative Medicine Research center, Velayat Burn University Hospital, Guilan University of Medical Sciences, Rasht, Iran

3 Department of Bio‑statistics, Social Determinants of Health Research Center (SDHRC), School of Nursing and Midwifery, Guilan University of Medical Sciences, Rasht, Iran

4 Cardiovascular Diseased Research Center, Department of Cardiology, Heshmat Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran

5 Burn and Regenerative Medicine Research center, Guilan University of Medical Sciences, Rasht, Iran

10.30476/beat.2022.97070.1399

Abstract

Objectives: To study the anti-inflammatory and antioxidant effects of flaxseed oil and olive oil on inflammatory
markers for facilitating wound healing.
Methods: One hundred and twelve patients were randomly selected to four groups with a total burn surface
area (TBSA) of 20-50%. The four groups includes olive oil (OO), flaxseed oil (FO), mixture of olive oil and
flaxseed oil (OF), and control group and received 30g of oils for three weeks. Serum high-sensitivity C-reactive
protein (hs-CRP), ferritin and albumin level as inflammatory markers, as well as cholesterol, triglyceride,
high-density lipoprotein (HDL) and low-density lipoprotein (LDL) as the lipid profile were explored. Wound
healing was assessed by photographing on days 2, 8, 15, and 22 (during three weeks of intervention) and were
analyzed in imageJ software.
Results: The greatest reduction in the level of hs-CRP and ferritin was observed in the OF (-21.38±44.41)
(-132.79±165.36), while the lowest reduction was reported in the control group (-36.36±79.03) (141.08±262.36).
Compared to control group, OO significantly increased albumin (0.88±0.65). Reduction of wound healing at the
end of the first week of intervention was not significant in the study groups. However, the stereology examination
showed significant improvement in wound healing at the end of the second and third weeks in the OF.
Conclusion: Based on the findings, combination of herbal oils reduce inflammation and improve wound healing
and showed positive effects on the size of wounds in burn patients.

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