Hany A. Zaki; Yavuz Yigit; Mohamed AM Elgassim; Eman E. Shaban; Stuart A Lloyd; Thamir Hashim; Mazin SE Mohamed; Aftab Mohammad Azad
Volume 12, Issue 3 , July 2024, , Pages 103-110
Abstract
Objective: The present study aimed to evaluate the clinical benefits and drawbacks of administering ECMO/ECLS therapies to drug-intoxicated patients.Methods: From inception until April 30, 2024, an extensive search was performed on four main databases:PubMed, Web of Science, Cochrane Library, and EMBASE. ...
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Objective: The present study aimed to evaluate the clinical benefits and drawbacks of administering ECMO/ECLS therapies to drug-intoxicated patients.Methods: From inception until April 30, 2024, an extensive search was performed on four main databases:PubMed, Web of Science, Cochrane Library, and EMBASE. There was no restriction on the search period. Onlythe studies that reported survival to hospital discharge rates, adverse events, and the utilization of ECMO/ECLSin the treatment of intoxicated patients were included. On the other hand, articles that did not report adverseevents or hospital discharge rates as outcomes, as well as studies published in languages other than English,were excluded. The evaluated outcomes were the rate of survival to hospital discharge rate and the incidenceof adverse events associated with ECMO therapy. The Newcastle Ottawa scale was employed to appraise eachstudy to determine its methodological quality. The Comprehensive Meta-Analysis (CMA) software (version3.0) for statistical analysis was used, with the random effects model (due to high heterogeneity among thestudies) and a 95% confidence interval.Results: From a total search of 2216 search results, only 10 studies were included. The pooled analysis from10 studies indicated that ECMO therapies among drug-overdosed/poisoned patients were associated witha significant survival to hospital discharge rate of 65.6% ([95% CI: 51.5%-77.4%], p=0.030). However, theoutcomes were highly heterogeneous (I2=83.47%), which could be attributed to the use of several medicinesby different studies. In contrast, ECMO therapies among drug-overdosed patients were associated with asignificant incidence rate of adverse events of 23.1% ([95% CI: 12.3%-39.2%], p=0.002). However, the pooledanalysis had a significant heterogeneity (I2=70.27%).Conclusion: Despite various health complications, extracorporeal membrane treatment enhanced survival tohospital discharge with good neurological outcomes. Hence, it was a viable, effective, and feasible alternativefor managing drug-induced intoxication in patients.
Eman E. Shaban; Yavuz Yigit; Mohamed AM Elgassim; Ahmed Shaban; Amira Shaban; Amin Ameen; Mohammed Abdurabu; Hany A. Zaki
Volume 12, Issue 2 , April 2024, , Pages 47-57
Abstract
Objective: This study aimed to compare the clinical risks and outcomes of COVID-19 and influenza.Methods: The search for relevant articles was conducted using both a database search method and a manualsearch, which involved searching through the reference lists of articles related to the topic for additional ...
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Objective: This study aimed to compare the clinical risks and outcomes of COVID-19 and influenza.Methods: The search for relevant articles was conducted using both a database search method and a manualsearch, which involved searching through the reference lists of articles related to the topic for additional studies.The Quality assessment was carried out using the Newcastle Ottawa tool, and the data analysis was conductedusing the Review Manager Software (RevMan 5.4.1).Results: The meta-analysis results indicated that COVID-19 patients had similar lengths of hospital stays(SMD: -0.25; 95% CI: -0.60-0.11; p=0.17). However, COVID-19 patients had significantly higher mortality rates(RR: 0.28; 95% CI: 0.21-0.37; p<0.0001), in-hospital complications (RR: 0.57; 95% CI: 0.50-0.65; p<0.00001),intensive care unit (ICU) admissions (OR: 0.48; 95% CI: 0.37-0.61; p<0.00001), length of ICU stay (SMD:-0.45; 95% CI: -0.83-0.06; p=0.02), and mechanical ventilation use (OR: 0.36; 95% CI: 0.28-0.46; p<0.00001).Conclusion: The findings suggested that COVID-19 was more severe than influenza. Therefore, “flu-like”symptoms should not be dismissed without a clear diagnosis, especially during the winter when influenza ismore prevalent.
