Document Type : Review Article


1 Cardiology, Al Jufairi Diagnosis and Treatment, MOH, Qatar

2 Hamad Medical Corporation

3 Hamad General Hospital

4 Internal Medicine - Mansoura General Hospital, Egypt.

5 Internal Medicine - Mansoura University Hospital, Egypt.



Objective: This study aimed to compare the clinical risks and outcomes of COVID-19 and influenza.
Methods: The search for relevant articles was conducted using both a database search method and a manual
search, which involved searching through the reference lists of articles related to the topic for additional studies.
The Quality assessment was carried out using the Newcastle Ottawa tool, and the data analysis was conducted
using the Review Manager Software (RevMan 5.4.1).
Results: The meta-analysis results indicated that COVID-19 patients had similar lengths of hospital stays
(SMD: -0.25; 95% CI: -0.60-0.11; p=0.17). However, COVID-19 patients had significantly higher mortality rates
(RR: 0.28; 95% CI: 0.21-0.37; p<0.0001), in-hospital complications (RR: 0.57; 95% CI: 0.50-0.65; p<0.00001),
intensive care unit (ICU) admissions (OR: 0.48; 95% CI: 0.37-0.61; p<0.00001), length of ICU stay (SMD:
-0.45; 95% CI: -0.83-0.06; p=0.02), and mechanical ventilation use (OR: 0.36; 95% CI: 0.28-0.46; p<0.00001).
Conclusion: The findings suggested that COVID-19 was more severe than influenza. Therefore, “flu-like”
symptoms should not be dismissed without a clear diagnosis, especially during the winter when influenza is
more prevalent.