Document Type : Letter to the Editor
Author
medical student, Clinical research development center, Amir oncology hospital, Shiraz University of Medical Sciences, Shiraz, Iran
Abstract
I commend the authors for their insightful manuscript "Effect of a Boswellia and Ginger Mixture on the Memory Dysfunction of the Mild Traumatic Brain Injury Patients: A Randomized, Double-Blind Controlled Trial(1)This study examines whether a combination of Boswellia (360 mg) and ginger (36 mg) taken three times per day (marketed as “Memoral”) can improve memory deficits in patients who have sustained a mild traumatic brain injury (mTBI). One hundred patients were randomized (1:1) into either the intervention or placebo groups. All participants had subjective complaints of memory dysfunction post-injury. Memory performance was assessed at baseline (about one-week post-discharge), after one month (when the intervention was complete), and after three months, using the Persian version of the Rey Auditory-Verbal Learning Test (AVLT).
Overall, this trial contributes valuable preliminary evidence that combining Boswellia and ginger may help hasten or strengthen recovery from memory dysfunction after mild TBI, at least over three months. The authors implemented a robust RCT methodology and demonstrated statistically significant improvements in several memory metrics (Total Learning, Retroactive Interference, Forgetting Rate, Net Positive Score) with no notable adverse effects.
However, replication in larger, multi-center cohorts (emphasizing longer follow-up, formal adherence checks, and additional potential confounders) is needed as with many single-center trials. Future investigations measuring inflammatory and oxidative markers would also help clarify the mechanism of action. Despite these limitations, the study’s design and results suggest that the Boswellia–ginger mixture holds promise as an adjunct therapy for post-mTBI memory dysfunction.
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