Sepsis and septic shock remain a major cause of morbidity and mortality globally. In septic patient’s bedside physical examination can often be unhelpful in helping to identify the source of infection and, therefore, decide upon appropriate management. Protocols for point-of-care-ultrasound (POCUS) in critically-ill patients who present with shock or trauma have been described elsewhere including rapid ultrasound in shock (RUSH), focused assessment with sonography for trauma (FAST), and focused cardiac ultrasound (FOCUS). Although the use of POCUS in sepsis has been reported in existing literature, there is not an algorithm for when POCUS is indicated in septic patients. We describe the case of a 70-year-old woman who presented to the emergency department (ED) with a 1-week history of diarrhoea and vomiting. The initial diagnosis in ED was viral gastroenteritis with prerenal acute kidney injury and she was initially referred to the medial team. However, the patient remained hypotensive and oliguric after 2 litters of IV fluids. A point-of-case-ultrasound (POCUS) showed a right kidney with moderate hydronephrosis. Urology team was immediately contacted with a CT that confirmed an obstructive stone causing moderate kidney hydronephrosis. Emergency nephrostomy was performed and the patient was discharged and has remained asymptomatic.