@article { author = {Karimipour, Mojtaba and Shojaei Zarghani, Sara and Mohajer Milani, Majid and Soraya, Hamid}, title = {Pre-Treatment with Metformin in Comparison with Post-Treatment Reduces Cerebral Ischemia Reperfusion Induced Injuries in Rats}, journal = {Bulletin of Emergency And Trauma}, volume = {6}, number = {Issue 2}, pages = {115-121}, year = {2018}, publisher = {Shiraz University of Medical Sciences}, issn = {2322-2522}, eissn = {2322-3960}, doi = {}, abstract = {Objective: To explore the effects of pre versus post ischemic treatment with metformin after global cerebral ischemia in rats.Methods: Male Wister rats underwent forebrain ischemia by bilateral common carotid artery occlusion for 17 min. Metformin (200 mg/kg) or vehicle was given orally by gavage for 7-14 days. Rats were divided into: control, metformin pre-treatment, metformin post-treatment and metformin pre and post continuous treatment groups. Cerebral infarct size, histopathology, myeloperoxidase and serum malondialdehyde were measured 7 days after ischemia.Results: Histopathological analysis showed that metformin pre-treatment significantly decreased leukocyte infiltration, myeloperoxidase activity and also malondialdehyde level. Metformin pre-treatment and metformin post-treatment reduced infarct size compared with the control group, but it was not significant in the pre and post continuous treatment group.Conclusion: Our findings suggest that pre-treatment with metformin in comparison with post-treatment in experimental stroke can reduce the extent of brain damage and is more neuroprotective at least in part by inhibiting oxidative stress and inflammation.}, keywords = {Global cerebral ischemia,Metformin,Oxidative stress,Inflammation}, url = {https://beat.sums.ac.ir/article_44420.html}, eprint = {https://beat.sums.ac.ir/article_44420_dd4db077ba007bf9b5ffecc678fe4686.pdf} }