Pre-Treatment with Metformin in Comparison with Post-Treatment Reduces Cerebral Ischemia Reperfusion Induced Injuries in Rats

Mojtaba Karimipour; Sara Shojaei Zarghani; Majid Mohajer Milani; Hamid Soraya

Volume 6, Issue 2 , April 2018, , Pages 115-121

Abstract
  Objective: To explore the effects of pre versus post ischemic treatment with metformin after global cerebral ischemia in rats.Methods: Male Wister rats underwent forebrain ischemia by bilateral common carotid artery occlusion for 17 min. Metformin (200 mg/kg) or vehicle was given orally by gavage for ...  Read More