TY - JOUR ID - 44443 TI - Hyperthermia and Rigidity Following Overdose of an Unknown Drug; A Case Report and Literature Review JO - Bulletin of Emergency And Trauma JA - BEAT LA - en SN - 2322-2522 AU - Dean-Paccagnella, Rose Cecile AU - Creed, Matthew AU - Kakollu, Mahendra AU - Gopala Pillai, Suresh Kumar AD - Abertawe Bro Morgannwg University Health Board Y1 - 2018 PY - 2018 VL - 6 IS - Issue 3 SP - 249 EP - 252 KW - Serotonin syndrome KW - Overdose KW - Hyperthermia KW - Hypertonicity DO - N2 - Drug induced hyperthermia is a rare presentation which can rapidly lead to gross metabolic abnormality and death. These presentations are further complicated by the wide range of potentially causative agents. We present a case of rigidity and hyperthermia, following overdose of an initially unknown substance leading to challenging management decisions in the Emergency Department. This case was later identified as Serotonin Syndrome. The patient presented with trismus which was managed with rapid sequence induction of anaesthesia to allow airway protection. On extubation a significant degree of laryngeal oedema complicated weaning, a possible complication of Serotonin Syndrome not previously described in the literature. We discuss the pathophysiology of Serotonin Syndrome, important differentials and practical considerations in managing hypertonicity of unknown origin in a young person. UR - https://beat.sums.ac.ir/article_44443.html L1 - https://beat.sums.ac.ir/article_44443_28941780eb3bb925f27a8cbf19bc1d91.pdf ER -